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环生医-桑楠教授、博导


  个人简介  

桑楠,女,中共党员,博士,教授,博士生导师,曾任2021俄罗斯欧洲杯官网院长,现2021欧洲杯官网党委书记,主要从事环境污染与健康方面的研究工作。

1995年毕业于2021俄罗斯欧洲杯环境科学系,获学士学位,同年免试推荐成为我校环境科学专业首届硕士研究生;19987月毕业于2021俄罗斯欧洲杯环境科学专业,获硕士学位,同年留校任教;19999月在职攻读2021俄罗斯欧洲杯环境科学专业博士研究生,20027月获博士学位;20047-20068月在美国路易斯安那州立大学健康科学中心(Louisiana University Health Science CenterLSUHSC)进行博士后研究。

研究方向:

主要从事环境科学专业环境毒理学方向的科研和教学工作。

承担主要课程:

环境生物学与实验,环境毒理学,细胞生物学

发表论文:

以第一作者或通讯作者发表SCI 核心期刊收录论文50篇,近五年发表SCI 收录论文30篇(SCI TOP 1区论文6篇),其中1篇发表在Environmental Health Perspectives上, 3篇发表在环境科学领域国际著名期刊Environmental Science & Technology上,2篇发表在Particle and Fibre Toxicology 杂志,1篇发表在Nature出版集团期刊Scientific Reports上,2篇发表在毒理学领域国际著名期刊Toxicological Science上,1篇发表在美国化学会唯一的化合物毒性研究期刊Chemical Research in Toxicology上。研究成果被Chemical ReviewsPhysiological ReviewsNature Reviews Neuroscience等学术期刊论文引用,累计他引700余次(全部论文近五年他引430次,单篇最高他引60次),并多次在国内外学术会议上交流。代表性论文:


  1. Han Ming,Guo ZhenLi GuangkeSang Nan(*)Nitrogen dioxide inhalation induces gene-toxicity in rats,Chemosphere20139011):2737-2742


  2. Zhu Na,Li HongyanLi GuangkeSang Nan(*)Coking wastewaterincreases micronucleus frequency in mouse in vivo via oxidative stressJournal of Environmental Sciences20132510):2123-2129


  3. Yun Yang (#),Yao Gaoyi (#)Yue HuifengGuo LinGuohua QinLiGuangkeSang Nan(*)SO2 inhalation causes synaptic injury in rat hippocampusvia its derivatives invivoChemosphere20139310):2426-2432


  4. Yao Gaoyi,Yue HuifengYun YangSang Nan(*)Chronic SO2 inhalationabove environmental standard impairs neuronal behavior and represses glutamatereceptor gene expression and memory- related kinase activation via neuro inflammation in ratsEnvironmental Research20151370):85-93


  5. Ji Xiaotong,Han MingYun YangLi GuangkeSang Nan(*)Acute nitrogen dioxide (NO2) exposure enhances airway inflammation via modulatingTh1/Th2 differentiation and activating JAK-STAT pathwayChemosphere20151200):722-728


  6. Ku Tingting,Yan WeiJia WuyaoYun YangZhu NaLi GuangkeSangNan(*)Characterization of synergistic embryo toxicity of nickel and buprofezin in zebrafishEnvironmental Science &Technology2015497):4600-4608


  7. Yun Yang,Gao RuiYue HuifengLi GuangkeZhu NaSang Nan(*)Synergistic effects of particulate matter (PM10) and SO2 on human non-small celllung cancer A549 via ROS-mediated NF-κB activationJournal of Environmental Sciences-China2015310):146-153


  8. Li Ben,Chen MinjunGuo LinYun YangLi GuangkeSang Nan(*)Endogenous 2-arachidonoylglycerol alleviates cyclooxygenases-2 elevation-mediated neuronal injury from SO2 inhalation via PPARγ pathwayToxicological Science20151472):535-548


  9. Yue Huifeng(#),Yun Yang(#)Gao RuiLi GuangkeSang Nan(*)Winter polycyclic aromatic hydrocarbon-bound particulate matter from peri-urban North China promotes lung cancer cell metastasisEnvironmental Science &Technology20154924):14484-14493


  10. Yan Wei(#) ,Yun Yang(#) Ku TingtingLi GuangkeSang Nan(*)NO2inhalation promotes Alzheimer’s disease-like progression:cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerollipase inhibition-targeted medicationScientific Reports, 2016622429


  11. Liang Dong (#),Zhu Na(#) Zhu HailinHu ZhiyongCao DuanlinSang Nan(*)Improvement of the polyoxometalate's performance in the asymmetricoxidation of styrene via combined with chiral ionic liquidCatalysis Communications2016790):49-52


  12. Yao Gaoyi, Yun Yang, Sang Nan(*). Differential effects between one week and four weeks exposure to same mass of SO2 on synaptic plasticity in rat hippocampus. Environmental Toxicology, 2016, 31:820-9.


  13. Zhang Yingying, Ji Xiaotong, Ku Tingting, Li Guangke, Sang Nan(*).Heavy metals bound to fine particulate matter from northern China induce season-dependent health risks: A study based on myocardial toxicity. Environmental Pollution, 2016, 216:380-90.


  14. Ji Xiaotong, Zhang Yingying, Ku Tingting, Yun Yang, Li Guangke, Sang Nan(*). MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway. Toxicological Research, 2016, 320: 1548-1560.


  15. Sun Haifeng, Guo Shuai, Zhu Na, Sang Nan(*), Chen Zhang. In situ determination of multiple polycyclic aromatic hydrocarbons uptake by crop leaf surfaces using multi-way models.Environmental Pollution, 2016, 218:523-529. 


  16. Ku Tingting, Ji Xiaotong, Zhang Yingying, Li Guangke, Sang Nan(*).PM2.5, SO2 and NO2 co-exposure impairs neuro behavior and induces mitochondrial injuries in the mouse brain. Chemosphere, 2016, 163:27-34. 


  17. Zhang Yingying,Ji XiaotongKu TingtingSang Nan(*)Inflammatory response and endothelial dysfunction in the hearts of mice co-exposed to SO2,NO2 and PM2.5Environmental Toxicology, 2016, 31(12):1996-2005


  18. Ji Xiaotong(#), Ku Tingting(#), Zhu N, Ning X, Wei W, Li G, Sang N(*).Potential hepatic toxicity of buprofezin at sublethal concentrations: ROS-mediated conversion of energy metabolism. Journal of Hazardous Materials, 2016, 320:176-186. 


  19. Li Ben, Chen Minjun, Guo Lin, Yun Yang, Li Guangke, Sang Nan(*). Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain.J Environ Sci (China). 2017, 51:265-274


  20. Ku Tingting(#),  Chen Minjun(#),  Li Ben,  Yun Yang,  Li Guangke, Sang Nan(*),Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation , Toxicological Research, 2017,6, 7-16.


  21. Yun Yang(#), Gao Rui(#), Yue Huifeng, Liu Xiaofang, Li Guangke, Sang Nan(*). Polycyclic aromatic hydrocarbon (PAH)-containing soils from coal gangue stacking areas contribute to epithelial to mesenchymal transition (EMT) modulation on cancer cell metastasis. Science of the Total Environment, 2017, 580:632-640.


  22. Chen Minjun, Li Ben, Sang Nan(*). Particulate matter (PM2.5) exposure season-dependently induces neuronal apoptosis and synaptic injuries. J Environ Sci (China). 2017, 54:336-345. 


  23. Ku Tinging, Li Ben, Gao Rui, Zhang Yingying, Yan Wei, Ji Xiaotong, Li Guangke, Sang Nan(*).NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration. Part Fibre Toxicol. 2017, 14(1):34.


  24. Ku Tingting, Zhang Yingying, Ji Xiaotong, Li Guangke, Sang Nan(*).PM2.5-bound metal metabolic distribution and coupled lipid abnormality at different developmental windows.Environmental Pollution, 2017, 228:354-362.


  25. Yue Huifeng,Yan WeiJi XiaotongGao RuiMa JuanRao ZiyuLiGuangkeSang Nan(*), Maternal Exposure of Balb/cMice to Indoor NO2 and AllergicAsthma Syndrome in Offspring at Adulthood with evaluation of DNA Methylation Associated Th2 PolarizationEnvironmental Health Perspectives, 2017, 125(9):097011.


  26. Yun Yang(#), Gao Rui(#), Yue Huifeng, Guo Lin, Li Guangke, Sang Nan(*). Sulfate Aerosols Promote Lung Cancer Metastasis by Epigenetically 2 Regulatingthe Epithelial-to-Mesenchymal Transition (EMT),Environmental Science &Technology, 2017, 51(19):11401-11411.


  27. Sun Haifeng, Feng Ruijie, Nan Yanli, Chen Zhang, Sang Nan(*).In-situ examination of graphene and graphene oxide impact on the depuration of phenanthrene and fluoranthene adsorbed onto spinach (Spinacia oleracea L.) leaf surfaces. Environmental Pollution, 2017,pii: S0269-7491(17)32893-2. 


  28. Li Ben, Guo Lin, Ku Tingting, Chen Minjun, Li Guangke, Sang Nan(*).PM2.5 exposure stimulates COX-2-mediated excitatory synaptic transmission via ROS-NF-κB pathway.Chemosphere, 2018, 190:124-134.


  29. Ji Xiaotong(#), Zhang Yingying(#), Li Guangke, Sang Nan(*).Potential Role of Inflammation in Associations between Particulate Matter and Heart Failure. Current Pharmaceutical Design. 2018. doi: 10.2174/1381612824666180110150550. 


  30. Ning Xia, Ku Tingting, Gao Rui, Ji Xiaotong, Li Guangke, Sang Nan(*). In vitro PPARγ agonistic potential of chitin synthesis inhibitors and their energy metabolism-related hepatotoxicity. Science of the Total Environment 2018, 615: 1126–1132.


  31. Zhang Yingying, Yan Wei, Ji Xiaotong, Yue Huifeng, Li Guangke, Sang Nan(*). Maternal NO2 exposure induces cardiac hypertrophy in male offspring via ROS-HIF-1α transcriptional regulation and aberrant DNA methylation modification of Csx/Nkx2.5. Arch Toxicol. 2018, 92(4):1563-1579.


  32. Yue Huifeng, Yan Wei, Ji Xiaotong, Zhang Yingying, Li Guangke (*), Sang Nan(*). Maternal exposure to NO2 enhances airway sensitivity to allergens in BALB/c mice through the JAK-STAT6 pathway. Chemosphere. 2018, 200:455-463.


  33. Ning Xia, Wang Yue, Yan Wei, Li Guangke, Sang Nan(*). Chitin synthesis inhibitors promote liver cancer cell metastasis via interfering with hypoxia-inducible factor 1α. Chemosphere. 2018, 206:231-237.


  34. Qin Guohua, Xia Jin, Zhang Yingying, Guo Lianghong, Chen Rui, Sang Nan(*). Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice. Part Fibre Toxicol. 2018, 15(1):27.


  35. Ning Xia, Li Ben, Ku Tingting, Guo Lin, Li Guangke, Sang Nan(*). Comprehensive hippocampal metabolite responses to PM2.5 in young mice. Ecotoxicol Environ Saf. 2018, 165:36-43.


  36. 韩明, 李广科, 桑楠(*). 慢性吸入二氧化氮诱发大鼠DNA-蛋白质交联和微核效应[J]. 应用与环境生物学报, 2013, 19(6):941-944.


  37. 侯美伊, 桑楠(*). 二氧化氮(NO2)吸入暴露对大鼠心肌线粒体的损伤作用[J]. 应用与环境生物学报, 2014, 20(6):1033-1038.


  38. 郭琳, 桑楠(*). 不同季节大气可吸入颗粒物(PM10)诱导小鼠原代培养神经元炎性及其级联损伤效应[J]. 环境科学学报, 2015, 35(1):311-316.


  39. 姚高毅, 桑楠(*). 低浓度SO2暴露诱导大鼠大脑皮层的炎症效应[J]. 应用与环境生物学报, 2015, 21(2):372-376.


  40. 张舒婕, 李广科, 桑楠(*). NO2吸入诱导小鼠肺组织上皮细胞间质转化及单酰基甘油酯酶抑制的保护作用[J]. 环境科学学报, 2016, 36(11):4272-4277.


  41. 库婷婷, 桑楠(*). 大气污染物复合暴露后血浆microRNA芯片分析[J].环境化学2016, 35(12): 2451~2459.


  42. 张胜男,桑楠(*). PM2.5暴露对小鼠肝脏能量代谢的影响. 环境科学学报,378):3207-3212. 

主持和参与主要科研项目 (近五年)

主持国家和省部级科研项目10余项,包括国家优秀青年科学基金项目、国家自然科学基金面上项目和教育部博士点基金(博导类)项目等:

序号

项目来源

项目类别

项目名称

项目

负责人

1

国家自然科学基金

优秀青年科学基金项目

化学环境污染与健康

桑楠

2

省市其他厅局

山西省回国留学人员科研资助项目

SO2吸入暴露与缺血性中风发生发展的相关性及其分子机制研究

桑楠

3

山西省教育厅

2012山西省高校中青年拔尖创新人才01

2012山西省高校中青年拔尖创新人才01

桑楠

4

省市其他厅局

山西省回国留学人员科研资助项目

基于microRNAs调控的大气污染诱导认知功能损伤研究

桑楠

5

山西省教育厅

青年三晋学者

山西省青年三晋学者

桑楠

6

山西省教育厅

高校优秀创新团队

高校优秀创新团队

桑楠

 

 

 

 

 

 

参与学术会议情况

(1) 桑楠, Injury target, toxic effect and molecular mechanism of main atmospheric pollutants, The 1st International High-Level Symposium on Toxicology and Health of Air Pollution (THAP), 北京, 2018.10.20-2018.10.22 (会议报告)

(2) 桑楠, 大气细颗粒物暴露与毒性机制研究, 第九届全国环境化学大会, 杭州, 2017.10.19-2017.10.22 (会议报告)

(3) 桑楠, 基于表观遗传调控研究空气污染物孕期暴露诱导子代心肺系统损伤, 第九届全国环境化学大会, 杭州, 2017.10.19-2017.10.22 (会议报告)

(4) 桑楠, Polycyclic aromatic hydrocarbon (PAH)‐containing soils from coal gangue stacking areas contribute to cancer development: PPARγ‐mediated epithelial to mesenchymal transition (EMT) modulation on cell metastasis, Beijing Symposium 2016 on Environmental Processes and Risks of Chemical Contaminants, 厦门, 2016.11.30-2016.12.2 (会议报告)

(5) 桑楠, 大气污染物健康效应研究, 第八届全国分析毒理学大会, 舟山, 2014.4.27-2014.4.29 (会议报告)

 

科研和教学获奖情况:

近年来,在学术和教学方面获得多项奖励和荣誉。2012年获得首届国家优秀青年科学基金资助,同时入选山西省高等学校中青年拔尖创新人才支持计划;2010年入选教育部新世纪优秀人才支持计划;2008年获得教育部霍英东青年教师奖,入选山西省高等学校优秀青年学术带头人支持计划。兼任SCI期刊Sci Total Environ编委(Editorial Board)、中文核心期刊《环境化学》编委。

2003年10月,获2021俄罗斯欧洲杯青年教师教学基本功竞赛一等奖;同年11月,获山西省第三届高等学校青年教师教学基本功竞赛二等奖,并由山西省劳动竞赛委员会记二等功一次;20049月,被授予山西省模范教师称号;20071月,获2021俄罗斯欧洲杯本科教学优秀奖;20082月,获山西省科学技术奖自然科学类三等奖;同年12月,获教育部第十一届霍英东青年教师奖三等奖;20107月,获山西省高等学校科技进步奖自然科学类一等奖。20113月,当选2010年度山西省教科文卫体系统十大杰出知识女性,荣获山西省2011年度知识女性创新成果奖20115月,获得2011转型跨越山西青年五四奖章表彰;2011320日,桑楠教授光荣入选2010年度教育部新世纪优秀人才支持计划,2012年入选山西省高等院校拔尖创新人才支持计划。

 

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